The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguishedscholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology andto their use for the general welfare. The members of the committee responsible for the reportwere chosen for their special competences and with regard for appropriate balance. NOTICE: The project that is the subject of this report was approved by the Governing Board of the NationalResearch Council, whose members are drawn from the councils of the National Academy of Sciences, the NationalAcademy of Engineering, and the Institute of Medicine.